BOULDER - Three Boulder Valley companies - two in Boulder and one in Broomfield - led the state in venture capital financing in the fourth quarter, receiving a total of $40.7 million from investors.

Accera Inc., a Broomfield-based company that is developing food that helps treat patients with Alzheimer's, led the state in the amount of venture capital financing received in the fourth quarter, with $15.7 million, according to a MoneyTree Report compiled by Pricewaterhouse Coopers and the National Venture Capital Association, based on data supplied by Thomson Reuters.

Tendril Networks Inc. in Boulder, an energy-software company received $15 million in the fourth quarter. Minute Key Inc. in Boulder, a consumer products company, received $10 million to build a computer hardware and software system, according to the report.

Ten of the 21 companies in Colorado that raised venture capital in the quarter were from Boulder or Broomfield counties. Those 10 companies raised more than $45.7 million of the $85.8 million raised in Colorado - a little more than half of the total for the state.

The other seven Boulder area companies that received venture capital financing in the fourth quarter were:

Lanx Inc. in Broomfield received $2 million for a spinal surgery device.

VictorOps Inc. in Lafayette received $1.6 million to develop a software platform.

EnVysion LLC in Louisville received $1.4 million. The company makes web-based video surveillance systems.

MobileDay Inc. in Boulder received $1 million to develop its mobile meeting platform.

Ubooly Inc. in Boulder received $300,000 to develop a toy application for mobile phones.

Lagrange Systems Inc. in Boulder received $300,000. The company makes cloud-based Internet applications.

Jarvis Labs LLC in Longmont, a business technology incubator, did not disclose the amount that it received.

In total, statewide venture capital funding of $85.8 million in the fourth quarter was down more than 52 percent from the previous quarter's funding of $179.8 million, according to the report. The number of deals, 21, also was down a little more than 25 percent from the 28 reported in the third quarter.

The drop in funding statewide was mirrored by a national drop of 10 percent in dollars and a 6 percent decline in deals, according to a press statement. Total fourth-quarter investment across the United States came in at $6.4 billion in 968 companies.

For the year, 99 Colorado companies received $559.7 million in venture capital financing in 2012. That was a 9.1 percent drop in financing from the $615.7 million received by 107 companies in 2011.